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Mahoro is an android created by VESPER to fight an alien invasion by Saint during the 1980s. She is fast and immensely powerful, and is considered to be a formidable opponent by her enemies.

Being an android, she has a limited life span. At the beginning of the story, she has just 398 days to live and VESPER gives her the freedom to do anything she wants. She chooses to become a maid for Suguru Misato: his father was her superior officer who was also killed (as collateral damage) when she killed an alien who had taken him hostage.

Mahoro has a very sunny disposition and is friendly to just about everyone—she becomes a welcome regular at the market and becomes famous at Suguru's school when it is made known that she is working for him. She also quickly becomes an excellent cook, able to emulate and recreate dishes from the best restaurants. She is also quite devoted to Suguru, with feelings for him reminiscent of both a doting mother and a shy girlfriend.

However, she is very hostile towards anything perverted. A good portion of the story's humour comes from Mahoro chasing after Suguru's secret stash of pornographic magazines which, given her training, she is easily able to find. She is well known for this attitude from her catch phrase: "Ecchi na no wa ikenai to omoimasu" ("I think that dirty thoughts are bad"). Mahoro and Shikijo-sensei's dislike of one another stems from the fact that Shikijo is constantly trying to engage in an illicit relationship with Suguru. As such, Mahoro is very protective of Suguru when it comes to Shikijo's advances towards him.

Mahoro is very concerned about appearances, refusing to wear normal clothes given her position as a maid. She is also obsessed with her small breasts, and some stories actually deal with her rivalry with Shikijo (who has very large breasts), as well as her techniques and requests to VESPER for larger breasts.

Mahoro retains access to many of her weapons and gadgets from her VESPER days, and is able to pull out her gun at any time. She also has access to the "silpheed", a backpack-like device which when worn on her back, allows her to fly, as well as her support mech, Slash. She is able to call both the Silpheed and Slash at a moment's notice from the badge she wears on her maid uniform. In addition, she also owns a fully equipped red 2001 BMW Z3 convertible and MV Agusta motorcycle.

Mahoro was created using Saint alien technology, so she has a true soul and a pure heart. Later in the series it is revealed that Mahoro is directly connected to the memories of Matthew, who occasionally advises her.

She had no surname until the name Andou (short for android) was created by Suguru.

Despite being an android, Mahoro (in addition to having feelings and emotions) is also able to eat, sleep, go to the bathroom, and feel pain.